Lack of Correlation Between Vasodilatation and Pharmacologically Induced Immediate Headache in Healthy Subjects

Messoud Ashina, Peer Tfelt-Hansen, Peter Dalgaard, Jes Olesen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: The causal relationship between experimental headache and vasodilatation has not been fully clarified. In the present study, we combined headache and vascular data from eight experimental studies and conducted detailed statistical analyses. Given that substances used in all these experiments were vasodilators we examined a possible correlation between headache scores and increases in arterial diameter.
Methods: We identified nine studies and retrieved raw data in 89 healthy subjects (46 females, 43 males), mean age 27 years (range 18–59 years). The following variables were collected: maximal median headache intensity scores on a verbal rating scale (VRS) during immediate headache (0–120 minutes); the mean velocity of blood flow in the middle cerebral artery (VmeanMCA); and the diameter of the frontal branch of the superficial temporal artery (STA) during the maximal median headache intensity.
Results: The scatter plots show no relationship between maximal headache score and the relative changes in VmeanMCA and diameter of the STA. The main analyses of covariance showed a significant effect only of heart rate on headache (p = .014). The interaction tests were insignificant for all variables.
Conclusions: The major outcome is a finding of no linear relationship between experimental immediate headache and dilatation of the MCA or STA.
Background: The causal relationship between experimental headache and vasodilatation has not been fully clarified. In the present study, we combined headache and vascular data from eight experimental studies and conducted detailed statistical analyses. Given that substances used in all these experiments were vasodilators we examined a possible correlation between headache scores and increases in arterial diameter.
Methods: We identified nine studies and retrieved raw data in 89 healthy subjects (46 females, 43 males), mean age 27 years (range 18–59 years). The following variables were collected: maximal median headache intensity scores on a verbal rating scale (VRS) during immediate headache (0–120 minutes); the mean velocity of blood flow in the middle cerebral artery (VmeanMCA); and the diameter of the frontal branch of the superficial temporal artery (STA) during the maximal median headache intensity.
Results: The scatter plots show no relationship between maximal headache score and the relative changes in VmeanMCA and diameter of the STA. The main analyses of covariance showed a significant effect only of heart rate on headache (p = .014). The interaction tests were insignificant for all variables.
Conclusions: The major outcome is a finding of no linear relationship between experimental immediate headache and dilatation of the MCA or STA.
LanguageEnglish
JournalCephalalgia
Volume31
Issue number6
Pages683-690
ISSN0333-1024
DOIs
StatePublished - 2011

Keywords

  • Headache
  • Vasodilatation
  • Experimental Model of Headache

Cite this

Ashina, Messoud ; Tfelt-Hansen, Peer ; Dalgaard, Peter ; Olesen, Jes. / Lack of Correlation Between Vasodilatation and Pharmacologically Induced Immediate Headache in Healthy Subjects. In: Cephalalgia. 2011 ; Vol. 31, No. 6. pp. 683-690
@article{d54e26a9b0604922a119ca73e8ec81f6,
title = "Lack of Correlation Between Vasodilatation and Pharmacologically Induced Immediate Headache in Healthy Subjects",
abstract = "Background: The causal relationship between experimental headache and vasodilatation has not been fully clarified. In the present study, we combined headache and vascular data from eight experimental studies and conducted detailed statistical analyses. Given that substances used in all these experiments were vasodilators we examined a possible correlation between headache scores and increases in arterial diameter.Methods: We identified nine studies and retrieved raw data in 89 healthy subjects (46 females, 43 males), mean age 27 years (range 18–59 years). The following variables were collected: maximal median headache intensity scores on a verbal rating scale (VRS) during immediate headache (0–120 minutes); the mean velocity of blood flow in the middle cerebral artery (VmeanMCA); and the diameter of the frontal branch of the superficial temporal artery (STA) during the maximal median headache intensity.Results: The scatter plots show no relationship between maximal headache score and the relative changes in VmeanMCA and diameter of the STA. The main analyses of covariance showed a significant effect only of heart rate on headache (p = .014). The interaction tests were insignificant for all variables.Conclusions: The major outcome is a finding of no linear relationship between experimental immediate headache and dilatation of the MCA or STA.",
keywords = "Headache, Vasodilatation, Experimental Model of Headache",
author = "Messoud Ashina and Peer Tfelt-Hansen and Peter Dalgaard and Jes Olesen",
year = "2011",
doi = "10.1177/0333102410394672",
language = "English",
volume = "31",
pages = "683--690",
journal = "Cephalalgia",
issn = "0333-1024",
publisher = "Sage Publications Ltd.",
number = "6",

}

Lack of Correlation Between Vasodilatation and Pharmacologically Induced Immediate Headache in Healthy Subjects. / Ashina, Messoud; Tfelt-Hansen, Peer; Dalgaard, Peter; Olesen, Jes.

In: Cephalalgia, Vol. 31, No. 6, 2011, p. 683-690.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Lack of Correlation Between Vasodilatation and Pharmacologically Induced Immediate Headache in Healthy Subjects

AU - Ashina,Messoud

AU - Tfelt-Hansen,Peer

AU - Dalgaard,Peter

AU - Olesen,Jes

PY - 2011

Y1 - 2011

N2 - Background: The causal relationship between experimental headache and vasodilatation has not been fully clarified. In the present study, we combined headache and vascular data from eight experimental studies and conducted detailed statistical analyses. Given that substances used in all these experiments were vasodilators we examined a possible correlation between headache scores and increases in arterial diameter.Methods: We identified nine studies and retrieved raw data in 89 healthy subjects (46 females, 43 males), mean age 27 years (range 18–59 years). The following variables were collected: maximal median headache intensity scores on a verbal rating scale (VRS) during immediate headache (0–120 minutes); the mean velocity of blood flow in the middle cerebral artery (VmeanMCA); and the diameter of the frontal branch of the superficial temporal artery (STA) during the maximal median headache intensity.Results: The scatter plots show no relationship between maximal headache score and the relative changes in VmeanMCA and diameter of the STA. The main analyses of covariance showed a significant effect only of heart rate on headache (p = .014). The interaction tests were insignificant for all variables.Conclusions: The major outcome is a finding of no linear relationship between experimental immediate headache and dilatation of the MCA or STA.

AB - Background: The causal relationship between experimental headache and vasodilatation has not been fully clarified. In the present study, we combined headache and vascular data from eight experimental studies and conducted detailed statistical analyses. Given that substances used in all these experiments were vasodilators we examined a possible correlation between headache scores and increases in arterial diameter.Methods: We identified nine studies and retrieved raw data in 89 healthy subjects (46 females, 43 males), mean age 27 years (range 18–59 years). The following variables were collected: maximal median headache intensity scores on a verbal rating scale (VRS) during immediate headache (0–120 minutes); the mean velocity of blood flow in the middle cerebral artery (VmeanMCA); and the diameter of the frontal branch of the superficial temporal artery (STA) during the maximal median headache intensity.Results: The scatter plots show no relationship between maximal headache score and the relative changes in VmeanMCA and diameter of the STA. The main analyses of covariance showed a significant effect only of heart rate on headache (p = .014). The interaction tests were insignificant for all variables.Conclusions: The major outcome is a finding of no linear relationship between experimental immediate headache and dilatation of the MCA or STA.

KW - Headache

KW - Vasodilatation

KW - Experimental Model of Headache

U2 - 10.1177/0333102410394672

DO - 10.1177/0333102410394672

M3 - Journal article

VL - 31

SP - 683

EP - 690

JO - Cephalalgia

T2 - Cephalalgia

JF - Cephalalgia

SN - 0333-1024

IS - 6

ER -