From Sleep Duration to Childhood Obesity: What are the Pathways?

Claudia Börnhorst, Sabrina Hense, Wolfgang Ahrens, Antje Hebestreit, Lucia Reisch, Gianvincenzo Barba, Rüdiger von Kries, Otmar Bay

    Research output: Contribution to journalJournal articlepeer-review

    Abstract

    Sleep duration has been identified as risk factor for obesity already in children. Besides investigating the role of fat mass (FM), this study addressed the question whether endocrine mechanisms act as intermediates in the association between sleep duration and overweight/obesity. Within the framework of the IDEFICS study, the present research was conducted in 609 German resident children aged 2–9 years with information on fasting insulin, C-reactive protein and cortisol levels next to anthropometric measurements and parental questionnaires. Emphasising methodological aspects, an age-specific measure of sleep duration was derived to account for alteration in sleep duration during childhood/period of growth. Multivariate linear regression and quantile regression models confirmed an inverse relationship between sleep duration and measures of overweight/obesity. The estimate for the association of sleep duration and body mass index (BMI) was approximately halved after adjustment for FM, but remained significant. The strength of this association was also markedly attenuated when adjusting for insulin mainly for the upper BMI quantiles (Q80, β = −0.36 vs. β = −0.26; Q95, β = −0.87 vs. β = −0.47). Adjustment for cortisol and CrP did not yield this attenuation. Conclusion: The inverse relationship between sleep duration and BMI is mainly explained by the association between sleep duration and FM. Insulin may explain part of this association, in particular at the upper tail of the BMI distribution.
    Original languageEnglish
    JournalEuropean Journal of Pediatrics
    Volume171
    Issue number7
    Pages (from-to)1029–1038
    Number of pages10
    ISSN0340-6199
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Cross Sectional Study
    • Sleep Duration
    • Children
    • Insulin
    • Fat Mass
    • BMI

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