Does the FTO Gene Interact with the Socioeconomic Status on the Obesity Development among Young European Children? Results from the IDEFICS study

Ronja Foraita, Frauke Günther, Wencke Gwozdz, Lucia Reisch, Paola Russo, Fabio Lauria, Alfonso Siani, Toomas Veidebaum, Michael Tornaritis, Licia Iacoviello, Krishna Vyncke, Yannis Pitsiladis, Staffan Mårild, Dénes Molnar, Luis A. Moreno, Karin Bammann, Iris Pigeot

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Background: Various twin studies revealed that the influence of genetic factors on psychological diseases or behaviour is more expressed in socioeconomically advantaged environments. Other studies predominantly show an inverse association between socioeconomic status (SES) and childhood obesity in Western developed countries. The aim of this study is to investigate whether the fat mass and obesity-associated (FTO) gene interacts with the SES on childhood obesity in a subsample (N=4406) of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort. Methods: A structural equation model (SEM) is applied with the latent constructs obesity, dietary intakes, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on childhood obesity. Further, a multiple group SEM is used to explore whether an interaction effect exists between the single nucleotide polymorphism rs9939609 within the FTO gene and SES. Results: Significant main effects are shown for physical activity and fitness (standardised β s = -0.113), SES (β s = -0.057) and the FTO homozygous AA risk genotype (β s = -0.177). The explained variance of obesity is ∼9%. According to the multiple group approach of SEM, we see an interaction between SES and FTO with respect to their effect on childhood obesity (Δχ 2 =7.3, df=2, P=0.03). Conclusion: Children carrying the protective FTO genotype TT seem to be more protected by a favourable social environment regarding the development of obesity than children carrying the AT or AA genotype.

    Original languageEnglish
    JournalInternational Journal of Obesity
    Volume39
    Issue number1
    Pages (from-to)1-6
    Number of pages6
    ISSN0307-0565
    DOIs
    Publication statusPublished - 2015

    Bibliographical note

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    Cite this

    Foraita, Ronja ; Günther, Frauke ; Gwozdz, Wencke ; Reisch, Lucia ; Russo, Paola ; Lauria, Fabio ; Siani, Alfonso ; Veidebaum, Toomas ; Tornaritis, Michael ; Iacoviello, Licia ; Vyncke, Krishna ; Pitsiladis, Yannis ; Mårild, Staffan ; Molnar, Dénes ; Moreno, Luis A. ; Bammann, Karin ; Pigeot, Iris. / Does the FTO Gene Interact with the Socioeconomic Status on the Obesity Development among Young European Children? Results from the IDEFICS study. In: International Journal of Obesity. 2015 ; Vol. 39, No. 1. pp. 1-6.
    @article{55175fe60fa6430789405ea17615569d,
    title = "Does the FTO Gene Interact with the Socioeconomic Status on the Obesity Development among Young European Children?: Results from the IDEFICS study",
    abstract = "Background: Various twin studies revealed that the influence of genetic factors on psychological diseases or behaviour is more expressed in socioeconomically advantaged environments. Other studies predominantly show an inverse association between socioeconomic status (SES) and childhood obesity in Western developed countries. The aim of this study is to investigate whether the fat mass and obesity-associated (FTO) gene interacts with the SES on childhood obesity in a subsample (N=4406) of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort. Methods: A structural equation model (SEM) is applied with the latent constructs obesity, dietary intakes, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on childhood obesity. Further, a multiple group SEM is used to explore whether an interaction effect exists between the single nucleotide polymorphism rs9939609 within the FTO gene and SES. Results: Significant main effects are shown for physical activity and fitness (standardised β s = -0.113), SES (β s = -0.057) and the FTO homozygous AA risk genotype (β s = -0.177). The explained variance of obesity is ∼9{\%}. According to the multiple group approach of SEM, we see an interaction between SES and FTO with respect to their effect on childhood obesity (Δχ 2 =7.3, df=2, P=0.03). Conclusion: Children carrying the protective FTO genotype TT seem to be more protected by a favourable social environment regarding the development of obesity than children carrying the AT or AA genotype.",
    author = "Ronja Foraita and Frauke G{\"u}nther and Wencke Gwozdz and Lucia Reisch and Paola Russo and Fabio Lauria and Alfonso Siani and Toomas Veidebaum and Michael Tornaritis and Licia Iacoviello and Krishna Vyncke and Yannis Pitsiladis and Staffan M{\aa}rild and D{\'e}nes Molnar and Moreno, {Luis A.} and Karin Bammann and Iris Pigeot",
    note = "CBS Library does not have access to the material",
    year = "2015",
    doi = "10.1038/ijo.2014.156",
    language = "English",
    volume = "39",
    pages = "1--6",
    journal = "International Journal of Obesity",
    issn = "0307-0565",
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    Foraita, R, Günther, F, Gwozdz, W, Reisch, L, Russo, P, Lauria, F, Siani, A, Veidebaum, T, Tornaritis, M, Iacoviello, L, Vyncke, K, Pitsiladis, Y, Mårild, S, Molnar, D, Moreno, LA, Bammann, K & Pigeot, I 2015, 'Does the FTO Gene Interact with the Socioeconomic Status on the Obesity Development among Young European Children? Results from the IDEFICS study', International Journal of Obesity, vol. 39, no. 1, pp. 1-6. https://doi.org/10.1038/ijo.2014.156

    Does the FTO Gene Interact with the Socioeconomic Status on the Obesity Development among Young European Children? Results from the IDEFICS study. / Foraita, Ronja; Günther, Frauke; Gwozdz, Wencke; Reisch, Lucia; Russo, Paola; Lauria, Fabio; Siani, Alfonso; Veidebaum, Toomas; Tornaritis, Michael; Iacoviello, Licia; Vyncke, Krishna; Pitsiladis, Yannis; Mårild, Staffan; Molnar, Dénes; Moreno, Luis A.; Bammann, Karin; Pigeot, Iris.

    In: International Journal of Obesity, Vol. 39, No. 1, 2015, p. 1-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Does the FTO Gene Interact with the Socioeconomic Status on the Obesity Development among Young European Children?

    T2 - Results from the IDEFICS study

    AU - Foraita, Ronja

    AU - Günther, Frauke

    AU - Gwozdz, Wencke

    AU - Reisch, Lucia

    AU - Russo, Paola

    AU - Lauria, Fabio

    AU - Siani, Alfonso

    AU - Veidebaum, Toomas

    AU - Tornaritis, Michael

    AU - Iacoviello, Licia

    AU - Vyncke, Krishna

    AU - Pitsiladis, Yannis

    AU - Mårild, Staffan

    AU - Molnar, Dénes

    AU - Moreno, Luis A.

    AU - Bammann, Karin

    AU - Pigeot, Iris

    N1 - CBS Library does not have access to the material

    PY - 2015

    Y1 - 2015

    N2 - Background: Various twin studies revealed that the influence of genetic factors on psychological diseases or behaviour is more expressed in socioeconomically advantaged environments. Other studies predominantly show an inverse association between socioeconomic status (SES) and childhood obesity in Western developed countries. The aim of this study is to investigate whether the fat mass and obesity-associated (FTO) gene interacts with the SES on childhood obesity in a subsample (N=4406) of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort. Methods: A structural equation model (SEM) is applied with the latent constructs obesity, dietary intakes, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on childhood obesity. Further, a multiple group SEM is used to explore whether an interaction effect exists between the single nucleotide polymorphism rs9939609 within the FTO gene and SES. Results: Significant main effects are shown for physical activity and fitness (standardised β s = -0.113), SES (β s = -0.057) and the FTO homozygous AA risk genotype (β s = -0.177). The explained variance of obesity is ∼9%. According to the multiple group approach of SEM, we see an interaction between SES and FTO with respect to their effect on childhood obesity (Δχ 2 =7.3, df=2, P=0.03). Conclusion: Children carrying the protective FTO genotype TT seem to be more protected by a favourable social environment regarding the development of obesity than children carrying the AT or AA genotype.

    AB - Background: Various twin studies revealed that the influence of genetic factors on psychological diseases or behaviour is more expressed in socioeconomically advantaged environments. Other studies predominantly show an inverse association between socioeconomic status (SES) and childhood obesity in Western developed countries. The aim of this study is to investigate whether the fat mass and obesity-associated (FTO) gene interacts with the SES on childhood obesity in a subsample (N=4406) of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort. Methods: A structural equation model (SEM) is applied with the latent constructs obesity, dietary intakes, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on childhood obesity. Further, a multiple group SEM is used to explore whether an interaction effect exists between the single nucleotide polymorphism rs9939609 within the FTO gene and SES. Results: Significant main effects are shown for physical activity and fitness (standardised β s = -0.113), SES (β s = -0.057) and the FTO homozygous AA risk genotype (β s = -0.177). The explained variance of obesity is ∼9%. According to the multiple group approach of SEM, we see an interaction between SES and FTO with respect to their effect on childhood obesity (Δχ 2 =7.3, df=2, P=0.03). Conclusion: Children carrying the protective FTO genotype TT seem to be more protected by a favourable social environment regarding the development of obesity than children carrying the AT or AA genotype.

    U2 - 10.1038/ijo.2014.156

    DO - 10.1038/ijo.2014.156

    M3 - Journal article

    VL - 39

    SP - 1

    EP - 6

    JO - International Journal of Obesity

    JF - International Journal of Obesity

    SN - 0307-0565

    IS - 1

    ER -