Does the FTO Gene Interact with the Socio‐Economic Status on the Obesity Development Among Young European Children?: Results from the IDEFICS Study

Ronja Foraita, Frauke Günther, Wencke Gwozdz, Lucia Reisch, Paola Russo, Fabio Lauria, Alfonso Siani, Toomas Veidebaum, Michael Tornaritis, Licia Iacoviello, Krishna Vyncke, Yannis Pitsiladis, Staffan Mårild, Denes Molnar, Luis A. Moreno, Karin Bammann, Iris Pigeot

    Research output: Contribution to conferencePosterResearchpeer-review

    Abstract

    Various twin studies revealed that the influence of genetic factors on psychological diseases or behavior is more expressed in socio‐economically advantaged environments. Other studies predominantly show an inverse relation between socio‐economic status (SES) and childhood obesity in western developed countries. The aim of this study is to investigate whether the FTO gene
    interacts with the socio‐economic status (SES) on childhood obesity in a subsample of the IDEFICS cohort (N=4406). A structural equation model (SEM) is applied with the latent constructs obesity,
    dietary habits, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on obesity. Further, a multiple group SEM is used
    to explore whether an interaction effect between the single nucleotide polymorphism rs9939609 within the FTO gene and SES exists. Overall model fit was inconsistent (RMSEA=0.05; CFI=0.79).
    Significant main effects are shown for SES (standardized βs=‐0.057), the FTO homozygous risk genotype AA (βs=0.177) and physical activity and fitness habits (βs=‐0.113). The explained variance of obesity is about 9%. The multiple group SEM shows that SES and FTO interact in their effect on childhood obesity (Δχ2=7.3, df=2, p=0.03) insofar as children carrying the protective TT genotype are more susceptible to a favorable social environment.
    Various twin studies revealed that the influence of genetic factors on psychological diseases or behavior is more expressed in socio‐economically advantaged environments. Other studies predominantly show an inverse relation between socio‐economic status (SES) and childhood obesity in western developed countries. The aim of this study is to investigate whether the FTO gene
    interacts with the socio‐economic status (SES) on childhood obesity in a subsample of the IDEFICS cohort (N=4406). A structural equation model (SEM) is applied with the latent constructs obesity,
    dietary habits, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on obesity. Further, a multiple group SEM is used
    to explore whether an interaction effect between the single nucleotide polymorphism rs9939609 within the FTO gene and SES exists. Overall model fit was inconsistent (RMSEA=0.05; CFI=0.79).
    Significant main effects are shown for SES (standardized βs=‐0.057), the FTO homozygous risk genotype AA (βs=0.177) and physical activity and fitness habits (βs=‐0.113). The explained variance of obesity is about 9%. The multiple group SEM shows that SES and FTO interact in their effect on childhood obesity (Δχ2=7.3, df=2, p=0.03) insofar as children carrying the protective TT genotype are more susceptible to a favorable social environment.

    Conference

    ConferenceThe 23rd Annual Meeting of the International Genetic Epidemiology Society
    Number23
    CountryAustria
    CityVienna
    Period28/08/201430/08/2014
    Internet address

    Cite this

    Foraita, R., Günther, F., Gwozdz, W., Reisch, L., Russo, P., Lauria, F., ... Pigeot, I. (2014). Does the FTO Gene Interact with the Socio‐Economic Status on the Obesity Development Among Young European Children? Results from the IDEFICS Study. Poster session presented at The 23rd Annual Meeting of the International Genetic Epidemiology Society, Vienna, Austria.
    Foraita, Ronja ; Günther, Frauke ; Gwozdz, Wencke ; Reisch, Lucia ; Russo, Paola ; Lauria, Fabio ; Siani, Alfonso ; Veidebaum, Toomas ; Tornaritis, Michael ; Iacoviello, Licia ; Vyncke, Krishna ; Pitsiladis, Yannis ; Mårild, Staffan ; Molnar, Denes ; Moreno, Luis A. ; Bammann, Karin ; Pigeot, Iris. / Does the FTO Gene Interact with the Socio‐Economic Status on the Obesity Development Among Young European Children? Results from the IDEFICS Study. Poster session presented at The 23rd Annual Meeting of the International Genetic Epidemiology Society, Vienna, Austria.1 p.
    @conference{b307a86848c34b7e8f78adcc5ab055b7,
    title = "Does the FTO Gene Interact with the Socio‐Economic Status on the Obesity Development Among Young European Children?: Results from the IDEFICS Study",
    abstract = "Various twin studies revealed that the influence of genetic factors on psychological diseases or behavior is more expressed in socio‐economically advantaged environments. Other studies predominantly show an inverse relation between socio‐economic status (SES) and childhood obesity in western developed countries. The aim of this study is to investigate whether the FTO geneinteracts with the socio‐economic status (SES) on childhood obesity in a subsample of the IDEFICS cohort (N=4406). A structural equation model (SEM) is applied with the latent constructs obesity,dietary habits, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on obesity. Further, a multiple group SEM is usedto explore whether an interaction effect between the single nucleotide polymorphism rs9939609 within the FTO gene and SES exists. Overall model fit was inconsistent (RMSEA=0.05; CFI=0.79).Significant main effects are shown for SES (standardized βs=‐0.057), the FTO homozygous risk genotype AA (βs=0.177) and physical activity and fitness habits (βs=‐0.113). The explained variance of obesity is about 9{\%}. The multiple group SEM shows that SES and FTO interact in their effect on childhood obesity (Δχ2=7.3, df=2, p=0.03) insofar as children carrying the protective TT genotype are more susceptible to a favorable social environment.",
    author = "Ronja Foraita and Frauke G{\"u}nther and Wencke Gwozdz and Lucia Reisch and Paola Russo and Fabio Lauria and Alfonso Siani and Toomas Veidebaum and Michael Tornaritis and Licia Iacoviello and Krishna Vyncke and Yannis Pitsiladis and Staffan M{\aa}rild and Denes Molnar and Moreno, {Luis A.} and Karin Bammann and Iris Pigeot",
    year = "2014",
    language = "English",
    note = "null ; Conference date: 28-08-2014 Through 30-08-2014",
    url = "http://www.geneticepi.org/iges-2014/",

    }

    Foraita, R, Günther, F, Gwozdz, W, Reisch, L, Russo, P, Lauria, F, Siani, A, Veidebaum, T, Tornaritis, M, Iacoviello, L, Vyncke, K, Pitsiladis, Y, Mårild, S, Molnar, D, Moreno, LA, Bammann, K & Pigeot, I 2014, 'Does the FTO Gene Interact with the Socio‐Economic Status on the Obesity Development Among Young European Children? Results from the IDEFICS Study', Vienna, Austria, 28/08/2014 - 30/08/2014, .

    Does the FTO Gene Interact with the Socio‐Economic Status on the Obesity Development Among Young European Children? Results from the IDEFICS Study. / Foraita, Ronja; Günther, Frauke; Gwozdz, Wencke; Reisch, Lucia; Russo, Paola; Lauria, Fabio; Siani, Alfonso; Veidebaum, Toomas ; Tornaritis, Michael; Iacoviello, Licia; Vyncke, Krishna; Pitsiladis, Yannis; Mårild, Staffan; Molnar, Denes; Moreno, Luis A.; Bammann, Karin; Pigeot, Iris.

    2014. Poster session presented at The 23rd Annual Meeting of the International Genetic Epidemiology Society, Vienna, Austria.

    Research output: Contribution to conferencePosterResearchpeer-review

    TY - CONF

    T1 - Does the FTO Gene Interact with the Socio‐Economic Status on the Obesity Development Among Young European Children?

    T2 - Results from the IDEFICS Study

    AU - Foraita,Ronja

    AU - Günther,Frauke

    AU - Gwozdz,Wencke

    AU - Reisch,Lucia

    AU - Russo,Paola

    AU - Lauria,Fabio

    AU - Siani,Alfonso

    AU - Veidebaum,Toomas

    AU - Tornaritis,Michael

    AU - Iacoviello,Licia

    AU - Vyncke,Krishna

    AU - Pitsiladis,Yannis

    AU - Mårild,Staffan

    AU - Molnar,Denes

    AU - Moreno,Luis A.

    AU - Bammann,Karin

    AU - Pigeot,Iris

    PY - 2014

    Y1 - 2014

    N2 - Various twin studies revealed that the influence of genetic factors on psychological diseases or behavior is more expressed in socio‐economically advantaged environments. Other studies predominantly show an inverse relation between socio‐economic status (SES) and childhood obesity in western developed countries. The aim of this study is to investigate whether the FTO geneinteracts with the socio‐economic status (SES) on childhood obesity in a subsample of the IDEFICS cohort (N=4406). A structural equation model (SEM) is applied with the latent constructs obesity,dietary habits, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on obesity. Further, a multiple group SEM is usedto explore whether an interaction effect between the single nucleotide polymorphism rs9939609 within the FTO gene and SES exists. Overall model fit was inconsistent (RMSEA=0.05; CFI=0.79).Significant main effects are shown for SES (standardized βs=‐0.057), the FTO homozygous risk genotype AA (βs=0.177) and physical activity and fitness habits (βs=‐0.113). The explained variance of obesity is about 9%. The multiple group SEM shows that SES and FTO interact in their effect on childhood obesity (Δχ2=7.3, df=2, p=0.03) insofar as children carrying the protective TT genotype are more susceptible to a favorable social environment.

    AB - Various twin studies revealed that the influence of genetic factors on psychological diseases or behavior is more expressed in socio‐economically advantaged environments. Other studies predominantly show an inverse relation between socio‐economic status (SES) and childhood obesity in western developed countries. The aim of this study is to investigate whether the FTO geneinteracts with the socio‐economic status (SES) on childhood obesity in a subsample of the IDEFICS cohort (N=4406). A structural equation model (SEM) is applied with the latent constructs obesity,dietary habits, physical activity and fitness habits, and parental SES to estimate the main effects of the latter three variables and a FTO polymorphism on obesity. Further, a multiple group SEM is usedto explore whether an interaction effect between the single nucleotide polymorphism rs9939609 within the FTO gene and SES exists. Overall model fit was inconsistent (RMSEA=0.05; CFI=0.79).Significant main effects are shown for SES (standardized βs=‐0.057), the FTO homozygous risk genotype AA (βs=0.177) and physical activity and fitness habits (βs=‐0.113). The explained variance of obesity is about 9%. The multiple group SEM shows that SES and FTO interact in their effect on childhood obesity (Δχ2=7.3, df=2, p=0.03) insofar as children carrying the protective TT genotype are more susceptible to a favorable social environment.

    M3 - Poster

    ER -

    Foraita R, Günther F, Gwozdz W, Reisch L, Russo P, Lauria F et al. Does the FTO Gene Interact with the Socio‐Economic Status on the Obesity Development Among Young European Children? Results from the IDEFICS Study. 2014. Poster session presented at The 23rd Annual Meeting of the International Genetic Epidemiology Society, Vienna, Austria.