DBDS Genomic Cohort, a Prospective and Comprehensive Resource for Integrative and Temporal Analysis of Genetic, Environmental and Lifestyle Factors Affecting Health of Blood Donors

Thomas Folkmann Hansen, Karina Banasik, Christian Erikstrup, Ole Birger Pedersen, David Westergaard, Piotr Jaroslaw Chmura, Kaspar Nielsen, Lise Thørner, Henrik Hjalgrim, Helene Paarup, Margit Anita Hørup Larsen, Mikkel Petersen, Poul Jennum, Steffen Andersen, Mette Nyegaard, Gregor Borut Ernst Jemec, Jes Olesen, Thomas Werge, Pär I. Johanssond, Erik Sørensen & 3 others Søren Brunak, Henrik Ullum, Kristoffer Sølvsten Burgdorf

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Abstract

Purpose: To establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.
Participants: Blood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.
Findings to date: The cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.
Future plans: To provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.
Original languageEnglish
Article numbere028401
JournalBMJ Open
Volume9
Issue number6
Number of pages7
DOIs
Publication statusPublished - 2019

Keywords

  • Genetics
  • Preventive medicine
  • Public health

Cite this

Folkmann Hansen, Thomas ; Banasik, Karina ; Erikstrup, Christian ; Pedersen, Ole Birger ; Westergaard, David ; Chmura, Piotr Jaroslaw ; Nielsen, Kaspar ; Thørner, Lise ; Hjalgrim, Henrik ; Paarup, Helene ; Hørup Larsen, Margit Anita ; Petersen, Mikkel ; Jennum, Poul ; Andersen, Steffen ; Nyegaard, Mette ; Jemec, Gregor Borut Ernst ; Olesen, Jes ; Werge, Thomas ; Johanssond, Pär I. ; Sørensen, Erik ; Brunak, Søren ; Ullum, Henrik ; Burgdorf, Kristoffer Sølvsten. / DBDS Genomic Cohort, a Prospective and Comprehensive Resource for Integrative and Temporal Analysis of Genetic, Environmental and Lifestyle Factors Affecting Health of Blood Donors. In: BMJ Open. 2019 ; Vol. 9, No. 6.
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abstract = "Purpose: To establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements. Participants: Blood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks. Findings to date: The cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements. Future plans: To provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.",
keywords = "Genetics, Preventive medicine, Public health, Genetics, Preventive medicine, Public health",
author = "{Folkmann Hansen}, Thomas and Karina Banasik and Christian Erikstrup and Pedersen, {Ole Birger} and David Westergaard and Chmura, {Piotr Jaroslaw} and Kaspar Nielsen and Lise Th{\o}rner and Henrik Hjalgrim and Helene Paarup and {H{\o}rup Larsen}, {Margit Anita} and Mikkel Petersen and Poul Jennum and Steffen Andersen and Mette Nyegaard and Jemec, {Gregor Borut Ernst} and Jes Olesen and Thomas Werge and Johanssond, {P{\"a}r I.} and Erik S{\o}rensen and S{\o}ren Brunak and Henrik Ullum and Burgdorf, {Kristoffer S{\o}lvsten}",
year = "2019",
doi = "10.1136/bmjopen-2018-028401",
language = "English",
volume = "9",
journal = "BMJ Open",
issn = "2044-6055",
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Folkmann Hansen, T, Banasik, K, Erikstrup, C, Pedersen, OB, Westergaard, D, Chmura, PJ, Nielsen, K, Thørner, L, Hjalgrim, H, Paarup, H, Hørup Larsen, MA, Petersen, M, Jennum, P, Andersen, S, Nyegaard, M, Jemec, GBE, Olesen, J, Werge, T, Johanssond, PI, Sørensen, E, Brunak, S, Ullum, H & Burgdorf, KS 2019, 'DBDS Genomic Cohort, a Prospective and Comprehensive Resource for Integrative and Temporal Analysis of Genetic, Environmental and Lifestyle Factors Affecting Health of Blood Donors', BMJ Open, vol. 9, no. 6, e028401. https://doi.org/10.1136/bmjopen-2018-028401

DBDS Genomic Cohort, a Prospective and Comprehensive Resource for Integrative and Temporal Analysis of Genetic, Environmental and Lifestyle Factors Affecting Health of Blood Donors. / Folkmann Hansen, Thomas; Banasik, Karina; Erikstrup, Christian; Pedersen, Ole Birger; Westergaard, David; Chmura, Piotr Jaroslaw; Nielsen, Kaspar; Thørner, Lise; Hjalgrim, Henrik; Paarup, Helene; Hørup Larsen, Margit Anita; Petersen, Mikkel; Jennum, Poul; Andersen, Steffen; Nyegaard, Mette; Jemec, Gregor Borut Ernst; Olesen, Jes; Werge, Thomas; Johanssond, Pär I.; Sørensen, Erik; Brunak, Søren; Ullum, Henrik; Burgdorf, Kristoffer Sølvsten.

In: BMJ Open, Vol. 9, No. 6, e028401, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - DBDS Genomic Cohort, a Prospective and Comprehensive Resource for Integrative and Temporal Analysis of Genetic, Environmental and Lifestyle Factors Affecting Health of Blood Donors

AU - Folkmann Hansen, Thomas

AU - Banasik, Karina

AU - Erikstrup, Christian

AU - Pedersen, Ole Birger

AU - Westergaard, David

AU - Chmura, Piotr Jaroslaw

AU - Nielsen, Kaspar

AU - Thørner, Lise

AU - Hjalgrim, Henrik

AU - Paarup, Helene

AU - Hørup Larsen, Margit Anita

AU - Petersen, Mikkel

AU - Jennum, Poul

AU - Andersen, Steffen

AU - Nyegaard, Mette

AU - Jemec, Gregor Borut Ernst

AU - Olesen, Jes

AU - Werge, Thomas

AU - Johanssond, Pär I.

AU - Sørensen, Erik

AU - Brunak, Søren

AU - Ullum, Henrik

AU - Burgdorf, Kristoffer Sølvsten

PY - 2019

Y1 - 2019

N2 - Purpose: To establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements. Participants: Blood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks. Findings to date: The cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements. Future plans: To provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.

AB - Purpose: To establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements. Participants: Blood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks. Findings to date: The cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements. Future plans: To provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.

KW - Genetics

KW - Preventive medicine

KW - Public health

KW - Genetics

KW - Preventive medicine

KW - Public health

U2 - 10.1136/bmjopen-2018-028401

DO - 10.1136/bmjopen-2018-028401

M3 - Journal article

VL - 9

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 6

M1 - e028401

ER -