Association Between Variants of Neuromedin U Gene and Taste Thresholds and Food Preferences in European Children

Results From the IDEFICS Study

Claudio Grippi, Wolfgang Ahrens, Kirsten Buchecker, Charalambos Chadjigeorgiou, Stefaan De Henauw, Anna C. Koni, Ronja Foraita, Lauren Lissner, Dénes Molnar, Luis Alberto Moreno, Yannis Pitsiladis, Lucia A. Reisch, Paola Russo, Alfonso Siani, Toomas Veidebaum, Licia Iacoviello, Francesco Gianfagna

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Aim: The neuropeptide neuromedin U (NMU) known for its role in appetite, feeding and energy balance could be involved in the control of food choice and taste sensitivity. We examined the association between NMU polymorphisms/haplotypes and taste thresholds and food preferences in a population of European children.
Methods: A total of 578 subjects from the IDEFICS study (mean age 7.5 ± 0.8 SD, boys 53.6%) with NMU genotype data and food preference (salty, fatty, sweet, flavour and umami food) and taste threshold (salt, fat, sweet, umami) tests available were analysed. Three single nucleotide polymorphisms (SNPs; rs6827359, T:C; rs12500837, T:C; rs9999653, C:T) of NMU gene were analyzed and five major haplotypes were inferred. The associations between genotypes and food preferences or taste thresholds were investigated (odds ratios –OR, adjusted for age, sex and country). A p < 0.05 after false discovery rate adjustment (pFDR) was considered statistically significant.
Results: The association between NMU genotypes and food preference showed two NMU SNPs associated with preference for food containing sodium glutamate (umami taste; rs6827359C, OR = 1.61, 95% confidence interval (CI):1.20–2.17; rs9999653T, OR = 1.59, 95%CI:1.18–2.13). In the haplotype analysis, the CTT haplotype showed an OR of 1.70 (95%CI:1.16–2.5) for the umami food preference, while CCT haplotype showed an OR of 1.63 (95%CI:1.11–2.40), compared to the most frequent haplotype (TTC). Carriers of CCT/CCT vs subjects with no CCT haplotype showed an OR of 4.78 (95%CI:1.86–12.30). Umami food preference was associated with low values of BMI z-score, arm circumferences, skinfolds and fat mass (pFDR<0.05). No association between NMU genetic variants and taste thresholds was found.
Conclusions
: This study shows for the first time in children an association between preference for umami food and a NMU haplotype, previously found associated with low BMI values.
Original languageEnglish
Article number104376
JournalAppetite
Volume142
Number of pages6
ISSN0195-6663
DOIs
Publication statusPublished - Nov 2019

Bibliographical note

Published online: 18. July 2019

Keywords

  • Food preferences
  • Umami
  • Neuromedin U
  • Neurology
  • Genetics
  • Obesity

Cite this

Grippi, C., Ahrens, W., Buchecker, K., Chadjigeorgiou, C., De Henauw, S., Koni, A. C., ... Gianfagna, F. (2019). Association Between Variants of Neuromedin U Gene and Taste Thresholds and Food Preferences in European Children: Results From the IDEFICS Study. Appetite, 142, [104376]. https://doi.org/10.1016/j.appet.2019.104376
Grippi, Claudio ; Ahrens, Wolfgang ; Buchecker, Kirsten ; Chadjigeorgiou, Charalambos ; De Henauw, Stefaan ; Koni, Anna C. ; Foraita, Ronja ; Lissner, Lauren ; Molnar, Dénes ; Moreno, Luis Alberto ; Pitsiladis, Yannis ; Reisch, Lucia A. ; Russo, Paola ; Siani, Alfonso ; Veidebaum, Toomas ; Iacoviello, Licia ; Gianfagna, Francesco. / Association Between Variants of Neuromedin U Gene and Taste Thresholds and Food Preferences in European Children : Results From the IDEFICS Study. In: Appetite. 2019 ; Vol. 142.
@article{ffcde111f7224c40ac4fc6b3d43013fd,
title = "Association Between Variants of Neuromedin U Gene and Taste Thresholds and Food Preferences in European Children: Results From the IDEFICS Study",
abstract = "Aim: The neuropeptide neuromedin U (NMU) known for its role in appetite, feeding and energy balance could be involved in the control of food choice and taste sensitivity. We examined the association between NMU polymorphisms/haplotypes and taste thresholds and food preferences in a population of European children.Methods: A total of 578 subjects from the IDEFICS study (mean age 7.5 ± 0.8 SD, boys 53.6{\%}) with NMU genotype data and food preference (salty, fatty, sweet, flavour and umami food) and taste threshold (salt, fat, sweet, umami) tests available were analysed. Three single nucleotide polymorphisms (SNPs; rs6827359, T:C; rs12500837, T:C; rs9999653, C:T) of NMU gene were analyzed and five major haplotypes were inferred. The associations between genotypes and food preferences or taste thresholds were investigated (odds ratios –OR, adjusted for age, sex and country). A p < 0.05 after false discovery rate adjustment (pFDR) was considered statistically significant.Results: The association between NMU genotypes and food preference showed two NMU SNPs associated with preference for food containing sodium glutamate (umami taste; rs6827359C, OR = 1.61, 95{\%} confidence interval (CI):1.20–2.17; rs9999653T, OR = 1.59, 95{\%}CI:1.18–2.13). In the haplotype analysis, the CTT haplotype showed an OR of 1.70 (95{\%}CI:1.16–2.5) for the umami food preference, while CCT haplotype showed an OR of 1.63 (95{\%}CI:1.11–2.40), compared to the most frequent haplotype (TTC). Carriers of CCT/CCT vs subjects with no CCT haplotype showed an OR of 4.78 (95{\%}CI:1.86–12.30). Umami food preference was associated with low values of BMI z-score, arm circumferences, skinfolds and fat mass (pFDR<0.05). No association between NMU genetic variants and taste thresholds was found.Conclusions: This study shows for the first time in children an association between preference for umami food and a NMU haplotype, previously found associated with low BMI values.",
keywords = "Food preferences, Umami, Neuromedin U, Neurology, Genetics, Obesity, Food preferences, Umami, Neuromedin U, Neurology, Genetics, Obesity",
author = "Claudio Grippi and Wolfgang Ahrens and Kirsten Buchecker and Charalambos Chadjigeorgiou and {De Henauw}, Stefaan and Koni, {Anna C.} and Ronja Foraita and Lauren Lissner and D{\'e}nes Molnar and Moreno, {Luis Alberto} and Yannis Pitsiladis and Reisch, {Lucia A.} and Paola Russo and Alfonso Siani and Toomas Veidebaum and Licia Iacoviello and Francesco Gianfagna",
note = "Published online: 18. July 2019",
year = "2019",
month = "11",
doi = "10.1016/j.appet.2019.104376",
language = "English",
volume = "142",
journal = "Appetite",
issn = "0195-6663",
publisher = "Elsevier",

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Grippi, C, Ahrens, W, Buchecker, K, Chadjigeorgiou, C, De Henauw, S, Koni, AC, Foraita, R, Lissner, L, Molnar, D, Moreno, LA, Pitsiladis, Y, Reisch, LA, Russo, P, Siani, A, Veidebaum, T, Iacoviello, L & Gianfagna, F 2019, 'Association Between Variants of Neuromedin U Gene and Taste Thresholds and Food Preferences in European Children: Results From the IDEFICS Study', Appetite, vol. 142, 104376. https://doi.org/10.1016/j.appet.2019.104376

Association Between Variants of Neuromedin U Gene and Taste Thresholds and Food Preferences in European Children : Results From the IDEFICS Study. / Grippi, Claudio; Ahrens, Wolfgang; Buchecker, Kirsten; Chadjigeorgiou, Charalambos; De Henauw, Stefaan; Koni, Anna C.; Foraita, Ronja; Lissner, Lauren; Molnar, Dénes; Moreno, Luis Alberto; Pitsiladis, Yannis; Reisch, Lucia A.; Russo, Paola; Siani, Alfonso; Veidebaum, Toomas; Iacoviello, Licia; Gianfagna, Francesco.

In: Appetite, Vol. 142, 104376, 11.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Association Between Variants of Neuromedin U Gene and Taste Thresholds and Food Preferences in European Children

T2 - Results From the IDEFICS Study

AU - Grippi, Claudio

AU - Ahrens, Wolfgang

AU - Buchecker, Kirsten

AU - Chadjigeorgiou, Charalambos

AU - De Henauw, Stefaan

AU - Koni, Anna C.

AU - Foraita, Ronja

AU - Lissner, Lauren

AU - Molnar, Dénes

AU - Moreno, Luis Alberto

AU - Pitsiladis, Yannis

AU - Reisch, Lucia A.

AU - Russo, Paola

AU - Siani, Alfonso

AU - Veidebaum, Toomas

AU - Iacoviello, Licia

AU - Gianfagna, Francesco

N1 - Published online: 18. July 2019

PY - 2019/11

Y1 - 2019/11

N2 - Aim: The neuropeptide neuromedin U (NMU) known for its role in appetite, feeding and energy balance could be involved in the control of food choice and taste sensitivity. We examined the association between NMU polymorphisms/haplotypes and taste thresholds and food preferences in a population of European children.Methods: A total of 578 subjects from the IDEFICS study (mean age 7.5 ± 0.8 SD, boys 53.6%) with NMU genotype data and food preference (salty, fatty, sweet, flavour and umami food) and taste threshold (salt, fat, sweet, umami) tests available were analysed. Three single nucleotide polymorphisms (SNPs; rs6827359, T:C; rs12500837, T:C; rs9999653, C:T) of NMU gene were analyzed and five major haplotypes were inferred. The associations between genotypes and food preferences or taste thresholds were investigated (odds ratios –OR, adjusted for age, sex and country). A p < 0.05 after false discovery rate adjustment (pFDR) was considered statistically significant.Results: The association between NMU genotypes and food preference showed two NMU SNPs associated with preference for food containing sodium glutamate (umami taste; rs6827359C, OR = 1.61, 95% confidence interval (CI):1.20–2.17; rs9999653T, OR = 1.59, 95%CI:1.18–2.13). In the haplotype analysis, the CTT haplotype showed an OR of 1.70 (95%CI:1.16–2.5) for the umami food preference, while CCT haplotype showed an OR of 1.63 (95%CI:1.11–2.40), compared to the most frequent haplotype (TTC). Carriers of CCT/CCT vs subjects with no CCT haplotype showed an OR of 4.78 (95%CI:1.86–12.30). Umami food preference was associated with low values of BMI z-score, arm circumferences, skinfolds and fat mass (pFDR<0.05). No association between NMU genetic variants and taste thresholds was found.Conclusions: This study shows for the first time in children an association between preference for umami food and a NMU haplotype, previously found associated with low BMI values.

AB - Aim: The neuropeptide neuromedin U (NMU) known for its role in appetite, feeding and energy balance could be involved in the control of food choice and taste sensitivity. We examined the association between NMU polymorphisms/haplotypes and taste thresholds and food preferences in a population of European children.Methods: A total of 578 subjects from the IDEFICS study (mean age 7.5 ± 0.8 SD, boys 53.6%) with NMU genotype data and food preference (salty, fatty, sweet, flavour and umami food) and taste threshold (salt, fat, sweet, umami) tests available were analysed. Three single nucleotide polymorphisms (SNPs; rs6827359, T:C; rs12500837, T:C; rs9999653, C:T) of NMU gene were analyzed and five major haplotypes were inferred. The associations between genotypes and food preferences or taste thresholds were investigated (odds ratios –OR, adjusted for age, sex and country). A p < 0.05 after false discovery rate adjustment (pFDR) was considered statistically significant.Results: The association between NMU genotypes and food preference showed two NMU SNPs associated with preference for food containing sodium glutamate (umami taste; rs6827359C, OR = 1.61, 95% confidence interval (CI):1.20–2.17; rs9999653T, OR = 1.59, 95%CI:1.18–2.13). In the haplotype analysis, the CTT haplotype showed an OR of 1.70 (95%CI:1.16–2.5) for the umami food preference, while CCT haplotype showed an OR of 1.63 (95%CI:1.11–2.40), compared to the most frequent haplotype (TTC). Carriers of CCT/CCT vs subjects with no CCT haplotype showed an OR of 4.78 (95%CI:1.86–12.30). Umami food preference was associated with low values of BMI z-score, arm circumferences, skinfolds and fat mass (pFDR<0.05). No association between NMU genetic variants and taste thresholds was found.Conclusions: This study shows for the first time in children an association between preference for umami food and a NMU haplotype, previously found associated with low BMI values.

KW - Food preferences

KW - Umami

KW - Neuromedin U

KW - Neurology

KW - Genetics

KW - Obesity

KW - Food preferences

KW - Umami

KW - Neuromedin U

KW - Neurology

KW - Genetics

KW - Obesity

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