A Within-sibling Pair Analysis of Lifestyle Behaviours and BMI Z-score in the Multi-centre I.Family Study

I.Family Consortium, Leonie Helen Bogl, Kirsten Mehlig, Timm Intemann, Guiomar Masip, Anna Keski-Rahkonen, Paola Russo, Nathalie Michels, Lucia A. Reisch, Valeria Pala, Laura Johnson, Dénes Molnar, Michalis Tornaritis, Toomas Veidebaum, Luis Alberto Moreno, Wolfgang Ahrens, Lauren Lissner, Jaakko Kaprio, Antje Hebestreit

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background and aims: By investigating differences in lifestyle behaviours and BMI in sibling pairs, family-level confounding is minimized and causal inference is improved, compared to cross-sectional studies of unrelated children. Thus, we aimed to investigate within-sibling pair differences in different lifestyle behaviours and differences in BMI z-scores in children and adolescents.
Methods and results: We examined three groups of sibling pairs 1) all same-sex sibling pairs with maximum 4 years age difference (n = 1209 pairs from 1072 families in 8 countries, mean age 10.7 years, standard deviation 2.4 years), 2) sibling pairs discordant for overweight (n = 262) and 3) twin pairs (n = 85). Usual dietary intake was estimated by 24-h recalls and time spent in light (LPA) and moderate-to-vigorous physical activity (MVPA) was measured by accelerometers. Screen time, sleep and dieting for weight loss were assessed by questionnaires.
Within all 3 groups of sibling pairs, more time in MVPA was associated with lower BMI z-score. Higher energy intake was associated with higher BMI z-score within twin pairs and within all sibling pairs who were not currently dieting for weight loss. Regarding LPA, screen time or sleep duration, no or inconsistent associations were observed for the three groups of sibling pairs.
Conclusions: MVPA and energy intake were associated with BMI differences within sibling and twin pairs growing up in the same home, thus independent of family-level confounding factors. Future studies should explore whether genetic variants regulating appetite or energy expenditure behaviours account for weight differences in sibling pairs.
Background and aims: By investigating differences in lifestyle behaviours and BMI in sibling pairs, family-level confounding is minimized and causal inference is improved, compared to cross-sectional studies of unrelated children. Thus, we aimed to investigate within-sibling pair differences in different lifestyle behaviours and differences in BMI z-scores in children and adolescents.
Methods and results: We examined three groups of sibling pairs 1) all same-sex sibling pairs with maximum 4 years age difference (n = 1209 pairs from 1072 families in 8 countries, mean age 10.7 years, standard deviation 2.4 years), 2) sibling pairs discordant for overweight (n = 262) and 3) twin pairs (n = 85). Usual dietary intake was estimated by 24-h recalls and time spent in light (LPA) and moderate-to-vigorous physical activity (MVPA) was measured by accelerometers. Screen time, sleep and dieting for weight loss were assessed by questionnaires.
Within all 3 groups of sibling pairs, more time in MVPA was associated with lower BMI z-score. Higher energy intake was associated with higher BMI z-score within twin pairs and within all sibling pairs who were not currently dieting for weight loss. Regarding LPA, screen time or sleep duration, no or inconsistent associations were observed for the three groups of sibling pairs.
Conclusions: MVPA and energy intake were associated with BMI differences within sibling and twin pairs growing up in the same home, thus independent of family-level confounding factors. Future studies should explore whether genetic variants regulating appetite or energy expenditure behaviours account for weight differences in sibling pairs.
LanguageEnglish
JournalNutrition, Metabolism & Cardiovascular Diseases
Volume29
Issue number6
Pages580-589
Number of pages10
ISSN0939-4753
DOIs
StatePublished - Jun 2019

Bibliographical note

Published online: 22. February 2019

Keywords

  • Overweight-discordant
  • Sibling pairs
  • Twin pairs
  • Body mass index
  • Energy intake
  • MVPA

Cite this

I.Family Consortium, Bogl, L. H., Mehlig, K., Intemann, T., Masip, G., Keski-Rahkonen, A., ... Hebestreit, A. (2019). A Within-sibling Pair Analysis of Lifestyle Behaviours and BMI Z-score in the Multi-centre I.Family Study. Nutrition, Metabolism & Cardiovascular Diseases, 29(6), 580-589. DOI: 10.1016/j.numecd.2019.01.017
I.Family Consortium ; Bogl, Leonie Helen ; Mehlig, Kirsten ; Intemann, Timm ; Masip, Guiomar ; Keski-Rahkonen, Anna ; Russo, Paola ; Michels, Nathalie ; Reisch, Lucia A. ; Pala, Valeria ; Johnson, Laura ; Molnar, Dénes ; Tornaritis, Michalis ; Veidebaum, Toomas ; Moreno, Luis Alberto ; Ahrens, Wolfgang ; Lissner, Lauren ; Kaprio, Jaakko ; Hebestreit, Antje. / A Within-sibling Pair Analysis of Lifestyle Behaviours and BMI Z-score in the Multi-centre I.Family Study. In: Nutrition, Metabolism & Cardiovascular Diseases. 2019 ; Vol. 29, No. 6. pp. 580-589
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title = "A Within-sibling Pair Analysis of Lifestyle Behaviours and BMI Z-score in the Multi-centre I.Family Study",
abstract = "Background and aims: By investigating differences in lifestyle behaviours and BMI in sibling pairs, family-level confounding is minimized and causal inference is improved, compared to cross-sectional studies of unrelated children. Thus, we aimed to investigate within-sibling pair differences in different lifestyle behaviours and differences in BMI z-scores in children and adolescents.Methods and results: We examined three groups of sibling pairs 1) all same-sex sibling pairs with maximum 4 years age difference (n = 1209 pairs from 1072 families in 8 countries, mean age 10.7 years, standard deviation 2.4 years), 2) sibling pairs discordant for overweight (n = 262) and 3) twin pairs (n = 85). Usual dietary intake was estimated by 24-h recalls and time spent in light (LPA) and moderate-to-vigorous physical activity (MVPA) was measured by accelerometers. Screen time, sleep and dieting for weight loss were assessed by questionnaires.Within all 3 groups of sibling pairs, more time in MVPA was associated with lower BMI z-score. Higher energy intake was associated with higher BMI z-score within twin pairs and within all sibling pairs who were not currently dieting for weight loss. Regarding LPA, screen time or sleep duration, no or inconsistent associations were observed for the three groups of sibling pairs.Conclusions: MVPA and energy intake were associated with BMI differences within sibling and twin pairs growing up in the same home, thus independent of family-level confounding factors. Future studies should explore whether genetic variants regulating appetite or energy expenditure behaviours account for weight differences in sibling pairs.",
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I.Family Consortium, Bogl, LH, Mehlig, K, Intemann, T, Masip, G, Keski-Rahkonen, A, Russo, P, Michels, N, Reisch, LA, Pala, V, Johnson, L, Molnar, D, Tornaritis, M, Veidebaum, T, Moreno, LA, Ahrens, W, Lissner, L, Kaprio, J & Hebestreit, A 2019, 'A Within-sibling Pair Analysis of Lifestyle Behaviours and BMI Z-score in the Multi-centre I.Family Study' Nutrition, Metabolism & Cardiovascular Diseases, vol. 29, no. 6, pp. 580-589. DOI: 10.1016/j.numecd.2019.01.017

A Within-sibling Pair Analysis of Lifestyle Behaviours and BMI Z-score in the Multi-centre I.Family Study. / I.Family Consortium; Bogl, Leonie Helen ; Mehlig, Kirsten; Intemann, Timm; Masip, Guiomar; Keski-Rahkonen, Anna; Russo, Paola; Michels, Nathalie; Reisch, Lucia A.; Pala, Valeria; Johnson, Laura; Molnar, Dénes; Tornaritis, Michalis; Veidebaum, Toomas; Moreno, Luis Alberto; Ahrens, Wolfgang; Lissner, Lauren; Kaprio, Jaakko; Hebestreit, Antje.

In: Nutrition, Metabolism & Cardiovascular Diseases, Vol. 29, No. 6, 06.2019, p. 580-589.

Research output: Contribution to journalJournal articleResearchpeer-review

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T1 - A Within-sibling Pair Analysis of Lifestyle Behaviours and BMI Z-score in the Multi-centre I.Family Study

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AU - Bogl,Leonie Helen

AU - Mehlig,Kirsten

AU - Intemann,Timm

AU - Masip,Guiomar

AU - Keski-Rahkonen,Anna

AU - Russo,Paola

AU - Michels,Nathalie

AU - Reisch,Lucia A.

AU - Pala,Valeria

AU - Johnson,Laura

AU - Molnar,Dénes

AU - Tornaritis,Michalis

AU - Veidebaum,Toomas

AU - Moreno,Luis Alberto

AU - Ahrens,Wolfgang

AU - Lissner,Lauren

AU - Kaprio,Jaakko

AU - Hebestreit,Antje

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N2 - Background and aims: By investigating differences in lifestyle behaviours and BMI in sibling pairs, family-level confounding is minimized and causal inference is improved, compared to cross-sectional studies of unrelated children. Thus, we aimed to investigate within-sibling pair differences in different lifestyle behaviours and differences in BMI z-scores in children and adolescents.Methods and results: We examined three groups of sibling pairs 1) all same-sex sibling pairs with maximum 4 years age difference (n = 1209 pairs from 1072 families in 8 countries, mean age 10.7 years, standard deviation 2.4 years), 2) sibling pairs discordant for overweight (n = 262) and 3) twin pairs (n = 85). Usual dietary intake was estimated by 24-h recalls and time spent in light (LPA) and moderate-to-vigorous physical activity (MVPA) was measured by accelerometers. Screen time, sleep and dieting for weight loss were assessed by questionnaires.Within all 3 groups of sibling pairs, more time in MVPA was associated with lower BMI z-score. Higher energy intake was associated with higher BMI z-score within twin pairs and within all sibling pairs who were not currently dieting for weight loss. Regarding LPA, screen time or sleep duration, no or inconsistent associations were observed for the three groups of sibling pairs.Conclusions: MVPA and energy intake were associated with BMI differences within sibling and twin pairs growing up in the same home, thus independent of family-level confounding factors. Future studies should explore whether genetic variants regulating appetite or energy expenditure behaviours account for weight differences in sibling pairs.

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I.Family Consortium, Bogl LH, Mehlig K, Intemann T, Masip G, Keski-Rahkonen A et al. A Within-sibling Pair Analysis of Lifestyle Behaviours and BMI Z-score in the Multi-centre I.Family Study. Nutrition, Metabolism & Cardiovascular Diseases. 2019 Jun;29(6):580-589. Available from, DOI: 10.1016/j.numecd.2019.01.017