Abstract
Methods and results: We examined three groups of sibling pairs 1) all same-sex sibling pairs with maximum 4 years age difference (n = 1209 pairs from 1072 families in 8 countries, mean age 10.7 years, standard deviation 2.4 years), 2) sibling pairs discordant for overweight (n = 262) and 3) twin pairs (n = 85). Usual dietary intake was estimated by 24-h recalls and time spent in light (LPA) and moderate-to-vigorous physical activity (MVPA) was measured by accelerometers. Screen time, sleep and dieting for weight loss were assessed by questionnaires.
Within all 3 groups of sibling pairs, more time in MVPA was associated with lower BMI z-score. Higher energy intake was associated with higher BMI z-score within twin pairs and within all sibling pairs who were not currently dieting for weight loss. Regarding LPA, screen time or sleep duration, no or inconsistent associations were observed for the three groups of sibling pairs.
Conclusions: MVPA and energy intake were associated with BMI differences within sibling and twin pairs growing up in the same home, thus independent of family-level confounding factors. Future studies should explore whether genetic variants regulating appetite or energy expenditure behaviours account for weight differences in sibling pairs.
Methods and results: We examined three groups of sibling pairs 1) all same-sex sibling pairs with maximum 4 years age difference (n = 1209 pairs from 1072 families in 8 countries, mean age 10.7 years, standard deviation 2.4 years), 2) sibling pairs discordant for overweight (n = 262) and 3) twin pairs (n = 85). Usual dietary intake was estimated by 24-h recalls and time spent in light (LPA) and moderate-to-vigorous physical activity (MVPA) was measured by accelerometers. Screen time, sleep and dieting for weight loss were assessed by questionnaires.
Within all 3 groups of sibling pairs, more time in MVPA was associated with lower BMI z-score. Higher energy intake was associated with higher BMI z-score within twin pairs and within all sibling pairs who were not currently dieting for weight loss. Regarding LPA, screen time or sleep duration, no or inconsistent associations were observed for the three groups of sibling pairs.
Conclusions: MVPA and energy intake were associated with BMI differences within sibling and twin pairs growing up in the same home, thus independent of family-level confounding factors. Future studies should explore whether genetic variants regulating appetite or energy expenditure behaviours account for weight differences in sibling pairs.
| Language | English |
|---|---|
| Journal | Nutrition, Metabolism & Cardiovascular Diseases |
| Volume | 29 |
| Issue number | 6 |
| Pages | 580-589 |
| Number of pages | 10 |
| ISSN | 0939-4753 |
| DOIs | |
| State | Published - Jun 2019 |
Bibliographical note
Published online: 22. February 2019
Keywords
- Overweight-discordant
- Sibling pairs
- Twin pairs
- Body mass index
- Energy intake
- MVPA
Cite this
}
A Within-sibling Pair Analysis of Lifestyle Behaviours and BMI Z-score in the Multi-centre I.Family Study. / I.Family Consortium; Bogl, Leonie Helen ; Mehlig, Kirsten; Intemann, Timm; Masip, Guiomar; Keski-Rahkonen, Anna; Russo, Paola; Michels, Nathalie; Reisch, Lucia A.; Pala, Valeria; Johnson, Laura; Molnar, Dénes; Tornaritis, Michalis; Veidebaum, Toomas; Moreno, Luis Alberto; Ahrens, Wolfgang; Lissner, Lauren; Kaprio, Jaakko; Hebestreit, Antje.
In: Nutrition, Metabolism & Cardiovascular Diseases, Vol. 29, No. 6, 06.2019, p. 580-589.Research output: Contribution to journal › Journal article › Research › peer-review
TY - JOUR
T1 - A Within-sibling Pair Analysis of Lifestyle Behaviours and BMI Z-score in the Multi-centre I.Family Study
AU - I.Family Consortium
AU - Bogl,Leonie Helen
AU - Mehlig,Kirsten
AU - Intemann,Timm
AU - Masip,Guiomar
AU - Keski-Rahkonen,Anna
AU - Russo,Paola
AU - Michels,Nathalie
AU - Reisch,Lucia A.
AU - Pala,Valeria
AU - Johnson,Laura
AU - Molnar,Dénes
AU - Tornaritis,Michalis
AU - Veidebaum,Toomas
AU - Moreno,Luis Alberto
AU - Ahrens,Wolfgang
AU - Lissner,Lauren
AU - Kaprio,Jaakko
AU - Hebestreit,Antje
N1 - Published online: 22. February 2019
PY - 2019/6
Y1 - 2019/6
N2 - Background and aims: By investigating differences in lifestyle behaviours and BMI in sibling pairs, family-level confounding is minimized and causal inference is improved, compared to cross-sectional studies of unrelated children. Thus, we aimed to investigate within-sibling pair differences in different lifestyle behaviours and differences in BMI z-scores in children and adolescents.Methods and results: We examined three groups of sibling pairs 1) all same-sex sibling pairs with maximum 4 years age difference (n = 1209 pairs from 1072 families in 8 countries, mean age 10.7 years, standard deviation 2.4 years), 2) sibling pairs discordant for overweight (n = 262) and 3) twin pairs (n = 85). Usual dietary intake was estimated by 24-h recalls and time spent in light (LPA) and moderate-to-vigorous physical activity (MVPA) was measured by accelerometers. Screen time, sleep and dieting for weight loss were assessed by questionnaires.Within all 3 groups of sibling pairs, more time in MVPA was associated with lower BMI z-score. Higher energy intake was associated with higher BMI z-score within twin pairs and within all sibling pairs who were not currently dieting for weight loss. Regarding LPA, screen time or sleep duration, no or inconsistent associations were observed for the three groups of sibling pairs.Conclusions: MVPA and energy intake were associated with BMI differences within sibling and twin pairs growing up in the same home, thus independent of family-level confounding factors. Future studies should explore whether genetic variants regulating appetite or energy expenditure behaviours account for weight differences in sibling pairs.
AB - Background and aims: By investigating differences in lifestyle behaviours and BMI in sibling pairs, family-level confounding is minimized and causal inference is improved, compared to cross-sectional studies of unrelated children. Thus, we aimed to investigate within-sibling pair differences in different lifestyle behaviours and differences in BMI z-scores in children and adolescents.Methods and results: We examined three groups of sibling pairs 1) all same-sex sibling pairs with maximum 4 years age difference (n = 1209 pairs from 1072 families in 8 countries, mean age 10.7 years, standard deviation 2.4 years), 2) sibling pairs discordant for overweight (n = 262) and 3) twin pairs (n = 85). Usual dietary intake was estimated by 24-h recalls and time spent in light (LPA) and moderate-to-vigorous physical activity (MVPA) was measured by accelerometers. Screen time, sleep and dieting for weight loss were assessed by questionnaires.Within all 3 groups of sibling pairs, more time in MVPA was associated with lower BMI z-score. Higher energy intake was associated with higher BMI z-score within twin pairs and within all sibling pairs who were not currently dieting for weight loss. Regarding LPA, screen time or sleep duration, no or inconsistent associations were observed for the three groups of sibling pairs.Conclusions: MVPA and energy intake were associated with BMI differences within sibling and twin pairs growing up in the same home, thus independent of family-level confounding factors. Future studies should explore whether genetic variants regulating appetite or energy expenditure behaviours account for weight differences in sibling pairs.
KW - Overweight-discordant
KW - Sibling pairs
KW - Twin pairs
KW - Body mass index
KW - Energy intake
KW - MVPA
KW - Overweight-discordant
KW - Sibling pairs
KW - Twin pairs
KW - Body mass index
KW - Energy intake
KW - MVPA
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U2 - 10.1016/j.numecd.2019.01.017
DO - 10.1016/j.numecd.2019.01.017
M3 - Journal article
VL - 29
SP - 580
EP - 589
JO - Nutrition, Metabolism & Cardiovascular Diseases
T2 - Nutrition, Metabolism & Cardiovascular Diseases
JF - Nutrition, Metabolism & Cardiovascular Diseases
SN - 0939-4753
IS - 6
ER -