Elevated plasma N-terminal (NT)-proBNP from the heart as well as white matter hyperintensities (WMH) in the brain predict cardiovascular (CV) mortality in the general population. The cause of poor prognosis associated with elevated P-NT-proBNP is not known but WMH precede strokes in high risk populations. We assessed the association between P-NT-proBNP and WMH or brain atrophy measured with magnetic resonance imaging (MRI) in type 2 diabetic patients, and age-matched controls.
Reinhard, H., Garde, E., Skimminge, A., Åkeson, P., Ramsøy, T. Z., Winther, K., Parving, H-H., Rossing, P., & K. Jacobsen, P. (2012). Plasma NT-proBNP and White Matter Hyperintensities in Type 2 Diabetic Patients. Cardiovascular Diabetology, 11(119), 119-127. https://doi.org/10.1186/1475-2840-11-119