Even when the research is completed successfully, the authors’ job is not done. They must craft the best possible manuscript for submission to a targeted journal, which will put the research into the best possible light and enhance the likelihood of eventual acceptance. This is the process of framing the manuscript, and for this chapter we sought the thoughts and opinions of experienced academic colleagues on how authors should optimally frame manuscripts for journal submission. Each contributor was asked to provide three to five pieces of advice for young scholars on this topic. Our objective is to provide some non-obvious recommendations to young scholars that would substantially improve the manuscript from the reviewers’ viewpoint. Our contributors present guidance on framing each section of the typical academic manuscript, from introduction to conclusion, as well as some suggestions for overall improvement. We conclude with summary remarks on the importance of putting in the time and effort to frame the manuscript effectively.