The governance of information technology (IT) in organizations—understood as the locus of key IT decision rights—is shaped by the emergence of new IT innovations, and can also proactively be designed to influence an organization’s ability to innovate through IT. The research presented in this paper contributes to the Information Systems literature by addressing the neglected interrelationship of IT governance and organizational technology adoption. Following a multi-method research paradigm, four consecutive studies have been conducted each in two contemporary adoption scenarios: (1) the implementation of Mobile Government (M-Government) services by public sector agencies, and (2) the implementation of Software as a Service (SaaS) delivery models for enterprise information systems. As a group the results of these studies extend the classic rationale of a strategy-structure fit underlying prior IT governance theory by demonstrating that (1) in public sector organizations more centralized governance can facilitate process and service innovations, and (2) for external delivery models such as SaaS efficiency strategies can favor a decentralization of IT decision rights. The eight studies provide relevant implications for IT decision makers in governmental and entrepreneurial contexts.